Select an upcoming Colon cruise itinerary list below to find a Colon sailing itinerary by destination, line, or ship.

Lindblad Expeditions
01/13/2027
8 Night South American Cruise
Exploring Arenal Volcano, Pearl Islands and the Panama Canal
on the Lindblad Expeditions Natl Geographic Quest departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
$6,801
$8,327
$8,947
01/17/2027
8 Night South American Cruise
Exploring Arenal Volcano, Pearl Islands and the Panama Canal
on the Lindblad Expeditions Natl Geographic Quest departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
$6,801
$8,327
$8,947
01/21/2027
8 Night South American Cruise
Exploring Arenal Volcano, Pearl Islands and the Panama Canal
on the Lindblad Expeditions Natl Geographic Quest departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
$6,801
$8,327
$8,947
Ponant
10/20/2026
10 Night South American Cruise
on the Ponant L'Austral departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
$5,690
$6,200
$12,250
11/07/2026
7 Night South American Cruise
on the Ponant Le Bellot departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
-
$5,580
$9,750
11/21/2026
10 Night South American Cruise
on the Ponant Le Bellot departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
-
$11,060
$16,490
12/18/2026
10 Night South American Cruise
on the Ponant Le Bellot departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
-
$9,980
$21,290
12/19/2026
10 Night South American Cruise
on the Ponant Le Laperouse departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
-
$10,490
$15,630
01/14/2027
10 Night South American Cruise
on the Ponant Le Bellot departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
-
$12,200
$18,206
01/15/2027
7 Night South American Cruise
on the Ponant Le Laperouse departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
-
$6,600
$10,360
02/26/2027
7 Night South American Cruise
on the Ponant Le Laperouse departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
-
$6,270
$10,960
03/12/2027
10 Night South American Cruise
on the Ponant Le Laperouse departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
-
$6,990
$11,430
04/08/2027
10 Night South American Cruise
on the Ponant Le Bellot departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
-
$7,350
$10,770
Royal Caribbean International
06/13/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$959
-
-
$2,609
06/20/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$1,119
$1,119
-
$1,619
06/27/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$663
$769
-
-
07/04/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$544
$668
-
$2,469
07/11/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$706
$712
$1,419
$2,539
07/18/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$794
$849
$1,967
$2,639
07/25/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$949
$1,049
-
$2,439
08/01/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$818
$984
-
$1,428
08/08/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$690
$736
-
$1,687
08/15/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$612
$620
$1,328
$1,829
08/22/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$636
$686
$1,099
$1,249
08/29/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$636
$706
$1,708
$1,249
09/05/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$706
$836
-
$2,369
09/12/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$746
$756
$1,928
$1,950
09/19/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$986
$1,026
-
$1,888
09/26/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$656
$767
$1,218
$1,419
10/03/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$569
$659
$1,148
$1,358
10/10/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$589
$599
$1,059
$1,039
10/17/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$639
$669
$1,029
$999
10/24/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$751
$776
$1,088
$1,218
10/31/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$766
$809
$1,363
$1,809
11/07/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$726
$756
$1,142
$1,269
11/14/2026
10 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$799
$936
$1,499
$1,469
12/19/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$869
$876
$1,428
$1,419
12/26/2026
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$1,469
$1,699
$2,459
$3,309
01/02/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$876
$1,006
$1,479
$1,529
01/09/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$926
$1,046
$1,489
$1,578
01/16/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$1,386
$1,386
$1,379
$1,549
01/23/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$1,206
$1,356
-
-
01/30/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$896
$936
$1,339
$1,459
02/06/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$946
$956
$1,288
$1,538
02/13/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$729
$746
$1,328
$1,957
02/20/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$686
$896
$1,158
$1,349
02/27/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$706
$916
$1,409
$1,398
03/06/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$726
$836
$1,269
$1,328
03/13/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$806
$886
$1,489
$1,608
03/20/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$959
$969
$1,389
$1,409
03/27/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$1,209
$1,259
$1,718
$1,829
04/03/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$755
$959
$1,444
$1,519
04/10/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$876
$989
$1,689
$1,578
04/17/2027
7 Night Southern Caribbean Cruise
on the Royal Caribbean International Grandeur of the Seas departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
$826
$1,009
$1,708
$1,414
Windstar Cruises
12/19/2026
7 Night Central America & Panama Canal Cruise
on the Windstar Cruises Wind Star departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
$2,404
-
-
12/19/2026
7 Night Central America & Panama Canal Cruise
Costa Rica & Panama Canal
on the Windstar Cruises Wind Star departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
Contact cruise line for pricing & availability
01/02/2027
7 Night Central America & Panama Canal Cruise
on the Windstar Cruises Wind Star departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
$3,104
-
-
01/02/2027
7 Night Central America & Panama Canal Cruise
Costa Rica & Panama Canal
on the Windstar Cruises Wind Star departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
Contact cruise line for pricing & availability
01/05/2027
7 Night Central America & Panama Canal Cruise
Costa Rica & Panama Canal
on the Windstar Cruises 3tar Legend departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
Contact cruise line for pricing & availability
01/05/2027
7 Night Central America & Panama Canal Cruise
on the Windstar Cruises 3tar Legend departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
$2,234
$3,494
$4,719
01/19/2027
7 Night Central America & Panama Canal Cruise
Costa Rica & Panama Canal
on the Windstar Cruises 3tar Legend departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
Contact cruise line for pricing & availability
01/19/2027
7 Night Central America & Panama Canal Cruise
Lima Machu Picchu Pre Cruise Tour to Panama
on the Windstar Cruises 3tar Legend departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
Contact cruise line for pricing & availability
01/19/2027
7 Night Central America & Panama Canal Cruise
on the Windstar Cruises 3tar Legend departing from Colon, Panama
Interior
Oceanview
Balcony
Suite
-
$2,234
$3,494
$4,719
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