1160 E Main StWytheville, VA 24382 Phone: +1 276-228-5517Fax: +1 540-228-7454Toll Free: +844-266-5696 Hotel E-mailHotel Website Classification 1 Moderate Tourist Class Commission Rooms Rates 10% 72 - Hoteliers! Is your information accurate? Update Here OYO Hotel Wytheville I-77 & I-81 Location & Neighborhood Downtown - 80 MI, 1 hr 30 min from Roanoke Regl airport. 1 MI from Wytheville NYNearest Cross Street: Loanmax Title LoansHotel Location: Suburban