28951 Los Alisos BlvdMission Viejo, CA 92692 Phone: +1 949-305-7200Fax: +1 949-305-7205Toll Free: +800-764-4614 Hotel E-mailHotel Website Classification 7 Superior First Class Commission Rooms Rates 10% 90 $189-$229 (USD) Hoteliers! Is your information accurate? Update Here Ayres Hotel & Spa Mission Viejo Location & Neighborhood Located off Hwy 241, NE of I-5 - 18 MI, 20 min from John Wayne airport. 5 MI from IrvineNearest Cross Street: Los Alisos & 241 Hwy