10247 Hwy 59Wharton, TX 77488 Phone: +1 979-282-8300Fax: +1 979-282-8312Toll Free: +800-050-1933 Hotel Website Classification 3 Superior Tourist Class Commission Rooms Rates 10% 62 $145-$164 (USD) Hoteliers! Is your information accurate? Update Here Holiday Inn Express Wharton Location & Neighborhood Off Hwy 59, next to the South Texas Medical Center - 60 MI from William P. Hobby airport.Hotel Location: Highway, Rural