100 Madonna RdSan Luis Obispo, CA 93405 Phone: +1 805-543-3000Fax: +1 805-787-0636Toll Free: +800-543-9666 Hotel E-mailHotel Website Classification 4 Moderate First Class Commission Rooms Rates 10% 110 $223-$457 (USD) Hoteliers! Is your information accurate? Update Here Madonna Inn Location & Neighborhood Close to downtown San Luis Obispo, CA - 4 MI, 10 min from San Luis Obispo Regl airport.Nearest Cross Street: Higuera StreetHotel Location: Beach, Tourist