1700 Commerce BlvdOpelousas, LA 70570 Phone: +1 337-284-3428Fax: +1 337-284-3579Toll Free: +800-426-7866 Hotel E-mailHotel Website Classification 3 Superior Tourist Class Commission Rooms Rates 10% 80 - Hoteliers! Is your information accurate? Update Here Hampton Inn Opelousas Location & Neighborhood 40 MI, 45 min from Lafayette Regl airport.