1252 North 12th StMiddlesboro, KY 40965 Phone: +1 606-248-6860Fax: +1 606-248-6978Toll Free: +800-082-0107 Hotel E-mailHotel Website Classification 3 Superior Tourist Class Commission Rooms Rates 10% 59 $112-$112 (USD) Hoteliers! Is your information accurate? Update Here Holiday Inn Express Middlesboro Location & Neighborhood US 25 E, Middlesboro KY - 65 MI, 1 hr 20 min from McGhee-Tyson airport. 60 MI from KnoxvilleHotel Location: Mountain