700 W Main StLouisville, KY 40202 Phone: +1 502-217-6300Fax: +1 502-217-6301Toll Free: +844-382-2267 Hotel E-mailHotel Website Classification 9 Deluxe Commission Rooms Rates 10% 91 $328-$579 (USD) Hoteliers! Is your information accurate? Update Here 21c Museum Hotel Louisville Location & Neighborhood Downtown on Museum Row. Close to museums, restaurants & attractions. - 8 MI, 15 min from Louisville Intl airport. 0 MI from LouisvilleNearest Cross Street: 7th