259 Main StHyannis, MA 02601 Phone: +1 508-827-1345Fax: +1 508-775-5687Toll Free: +877-424-6423 Hotel E-mailHotel Website Classification 4 Moderate First Class Commission Rooms Rates 10% 93 $149-$149 (USD) Hoteliers! Is your information accurate? Update Here Comfort Inn Hyannis - Cape Cod Location & Neighborhood Main Street Waterfront District near Hyannis Harbor - 1 KM, 5 min from Barnstable airport.Nearest Cross Street: Old Colony RdHotel Location: Beach, Lake, Tourist