3603 McMasters AveHannibal, MO 63401 Phone: +1 573-221-7950Fax: +1 573-221-6395 Classification 2 Tourist Class Commission Rooms Rates 10% 64 - Hoteliers! Is your information accurate? Update Here Mark Twain Motor Inn Location & Neighborhood Junction of Hwys 36 & 61, 2 mi west of Mark Twain's home - 100 MI, 2 hr from St Louis/Lambert airport.Hotel Location: Highway