Select an upcoming Panama City cruise itinerary list below to find a Panama City sailing itinerary by destination, line, or ship. Search All Cruises Oceania Cruises01/15/202710 Night Central America & Panama Canal Cruiseon the Oceania Cruises Marina departing from Panama City, PanamaInteriorOceanviewBalconySuite--$3,839$9,13903/15/202710 Night Central America & Panama Canal Cruiseon the Oceania Cruises Marina departing from Panama City, PanamaInteriorOceanviewBalconySuite$1,349$2,069$2,549$3,909Regent Seven Seas Cruises01/26/202728 Night Oceania & South Pacific Cruiseon the Regent Seven Seas Cruises Seven Seas Splendor departing from Panama City, PanamaInteriorOceanviewBalconySuite---$14,11002/22/202711 Night Central America & Panama Canal Cruiseon the Regent Seven Seas Cruises Seven Seas Prestige departing from Panama City, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability03/09/202722 Night South American Cruiseon the Regent Seven Seas Cruises Seven Seas Grandeur departing from Panama City, PanamaInteriorOceanviewBalconySuite---$18,04703/31/202714 Night Central America & Panama Canal Cruiseon the Regent Seven Seas Cruises Seven Seas Grandeur departing from Panama City, PanamaInteriorOceanviewBalconySuite---$6,839Scenic10/26/20269 Night South American Cruise Wellness Retreaton the Scenic Scenic Eclipse departing from Panama City, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability10/26/20269 Night South American Cruise Wellness Retreat - Panama City to Valparaisoon the Scenic Scenic Eclipse departing from Panama City, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability04/03/202711 Night Southern Caribbean Cruise Pristine Islands of the Caribbean & the Panama Canalon the Scenic Scenic Eclipse II departing from Panama City, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availabilityThe Ritz-Carlton Yacht Collection03/28/20277 Night Caribbean Cruiseon the The Ritz-Carlton Yacht Collection Evrima departing from Panama City, PanamaInteriorOceanviewBalconySuite---$7,600Viking Ocean11/13/202610 Night Caribbean Cruiseon the Viking Ocean Viking Mars departing from Panama City, PanamaInteriorOceanviewBalconySuite--$4,999-12/17/202610 Night Caribbean Cruiseon the Viking Ocean Viking Mars departing from Panama City, PanamaInteriorOceanviewBalconySuite--$3,999$6,499