Select an upcoming Panama City cruise itinerary list below to find a Panama City sailing itinerary by destination, line, or ship. Search All Cruises Crystal12/10/202611 Night Caribbean Cruiseon the Crystal Crystal Serenity departing from Panama City, PanamaInteriorOceanviewBalconySuite-$4,700$5,400$5,90008/20/202714 Night Caribbean Cruiseon the Crystal Crystal Serenity departing from Panama City, PanamaInteriorOceanviewBalconySuite-$5,100$6,800$7,000Oceania Cruises01/15/202710 Night Central America & Panama Canal Cruiseon the Oceania Cruises Marina departing from Panama City, PanamaInteriorOceanviewBalconySuite$1,849$2,758$3,508$5,60803/15/202710 Night Central America & Panama Canal Cruiseon the Oceania Cruises Marina departing from Panama City, PanamaInteriorOceanviewBalconySuite$2,808$3,908$4,058$6,458Regent Seven Seas Cruises01/26/202728 Night Oceania & South Pacific Cruiseon the Regent Seven Seas Cruises Seven Seas Splendor departing from Panama City, PanamaInteriorOceanviewBalconySuite---$18,79902/22/202711 Night Central America & Panama Canal Cruiseon the Regent Seven Seas Cruises Seven Seas Prestige departing from Panama City, PanamaInteriorOceanviewBalconySuite---$10,34703/09/202722 Night South American Cruiseon the Regent Seven Seas Cruises Seven Seas Grandeur departing from Panama City, PanamaInteriorOceanviewBalconySuite---$22,52203/31/202714 Night Central America & Panama Canal Cruiseon the Regent Seven Seas Cruises Seven Seas Grandeur departing from Panama City, PanamaInteriorOceanviewBalconySuite---$8,389Scenic04/03/202711 Night Southern Caribbean Cruise Pristine Islands of the Caribbean & the Panama Canalon the Scenic Scenic Eclipse II departing from Panama City, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability10/31/202713 Night South American Cruise Ancient Kingdoms and Natural Treasures: Panama to Chileon the Scenic Scenic Eclipse departing from Panama City, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability10/31/202725 Night South American Cruise Ultimate Ancient Treasures, Fjords & Wonders of South Americaon the Scenic Scenic Eclipse departing from Panama City, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availabilityThe Ritz-Carlton Yacht Collection03/28/20277 Night Caribbean Cruiseon the The Ritz-Carlton Yacht Collection Evrima departing from Panama City, PanamaInteriorOceanviewBalconySuite---$7,600Viking Ocean11/13/202610 Night Caribbean Cruiseon the Viking Ocean Viking Mars departing from Panama City, PanamaInteriorOceanviewBalconySuite--$3,799$6,29911/29/202710 Night Caribbean Cruiseon the Viking Ocean Viking Mars departing from Panama City, PanamaInteriorOceanviewBalconySuite--$4,899$6,999